Case Studies · Clinical Commentary · Diagnostic Insights
Histopathology IHC · LBC · BMT Specialist Review
Featured
Case Study
Diagnostic challenges in triple-negative breast carcinoma: an IHC case series from a Karachi cohort
Histopathology & IHCDr. [Author Name][Month] [Year]12 min read
A review of [n] consecutive triple-negative breast carcinoma cases referred over a 24-month period — examining IHC panel performance, inter-observer variability in a multi-pathologist setting, and the implications for clinical management in a South Asian population. The cases raise questions about the applicability of Western IHC thresholds to locally-processed tissue and locally-presenting demographics.
A rare presentation of primary hepatic carcinoid tumour: morphological and IHC findings
Carcinoid tumours of the liver are rare — this case documents the diagnostic pathway, IHC panel selection, and the differentials considered in a referred specimen from a tertiary hospital.
Article
The multi-pathologist model: why a second pair of eyes changes diagnostic outcomes
An evidence-based case for multi-pathologist review in histopathology — examining discordance rates in single-pathologist vs panel settings, and what the literature says about clinical impact.
Newsletter
Laboratory Quarterly — [Q/Year]: Programme updates, new capabilities, and selected cases
This quarter's update covers recent IHC panel additions, a note on BMT programme volume, turnaround time data, and a brief from the pathologist panel on diagnostic trends observed this period.
Case Study
Bone marrow biopsy in a post-transplant patient: interpreting H&E and IHC in the BMT context
Twenty years of BMT tissue support has generated a significant body of observational experience. This case illustrates how post-transplant bone marrow morphology is interpreted differently from de-novo presentations.
Article
IHC in resource-constrained settings: prioritising panels when cost is a clinical reality
Not every patient can afford a full IHC panel. This article addresses how pathologists can triage marker selection to maximise diagnostic yield when clinical resources are limited.
Case Study
Clinicopathological correlation in a case of oral squamous cell carcinoma with unexpected IHC profile
A referred case from a head and neck surgeon presented with a clinical picture that diverged from the histological and IHC findings — documenting the diagnostic resolution and its clinical implications.
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